Thermo Fisher Scientific Phospho-c-Abl (Tyr89) Monoclonal Antibody (C.635.9)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

ChIP Assay (ChIP)

• Tested Dilution: 1–3 µL

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, the c-Abl gene undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl with the Bcr gene.
c-Abl was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) and may regulate DNA repair by activating proapoptotic pathways under severe DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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