Thermo Fisher Scientific Phospho-c-Abl (Tyr89) Monoclonal Antibody (C.635.9)
Human c-Abl 단백질의 Tyr89 인산화 상태를 특이적으로 인식하는 rabbit monoclonal antibody입니다. Western blot 및 ChIP assay에 적합하며, 고순도 affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
ChIP Assay (ChIP)
- Tested Dilution: 1–3 µL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.635.9 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr89 of human c-Abl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985977 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, the c-Abl gene undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl with the Bcr gene.
c-Abl was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) and may regulate DNA repair by activating proapoptotic pathways under severe DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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