Thermo Fisher Scientific CD43 Polyclonal Antibody
Thermo Fisher Scientific의 CD43 Polyclonal Antibody는 인간 CD43 단백질을 특이적으로 인식하는 rabbit polyclonal 항체입니다. Western blot과 immunoprecipitation에 적합하며, 보존제가 포함되지 않아 장기 보관 시 sodium azide 추가를 권장합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1–2 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human SPN/CD43 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788293 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human SPN/CD43.
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells.
CD43 contributes to a repulsive barrier that interferes with cellular adhesion, but can also promote leukocyte aggregation.
Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness while counteracting LFA-1 induction via other receptors.
Expression of CD43 induces functionally active tumor suppressor p53 protein, but in the absence of p53 and ARF, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-81041_CD43_P16150-1_Rabbit.svg, PA5-81041_CD43_P16150-1_Rabbit_PDP.jpeg)
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