Thermo Fisher Scientific CD43 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunoprecipitation (IP)

• Tested Dilution: 1–2 µL/mg of lysate

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human SPN/CD43.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells.
CD43 contributes to a repulsive barrier that interferes with cellular adhesion, but can also promote leukocyte aggregation.
Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness while counteracting LFA-1 induction via other receptors.
Expression of CD43 induces functionally active tumor suppressor p53 protein, but in the absence of p53 and ARF, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-81041_CD43_P16150-1_Rabbit.svg, PA5-81041_CD43_P16150-1_Rabbit_PDP.jpeg)