Thermo Fisher Scientific CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Mouse Monoclonal Antibody (rCFTR, 1342)
CFTR 단백질을 인식하는 Thermo Fisher의 재조합 마우스 단일클론 항체로, 인간 및 마우스 시료에 반응합니다. IHC(P) 검증 완료, HEK293 세포 발현, Protein A/G 정제, PBS 버퍼 내 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rCFTR, 1342 |
| Immunogen | Recombinant full-length human CFTR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the CFTR gene, which encodes a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), resulting in abnormal chloride transport. This mutation leads to severe lung and liver disease. Interestingly, CFTR also serves as an entry point for Salmonella typhi into intestinal epithelial cells, and ΔF508 heterozygous and homozygous mice show significantly reduced bacterial uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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