Thermo Fisher Scientific Placental Alkaline Phosphatase (PLAP) (Germ Cell Tumor Marker) Monoclonal Antibody (SPM593)
인체 PLAP 단백질을 표적으로 하는 단클론 항체로, 생식세포 종양 마커 검출에 적합합니다. IHC, ICC, Flow Cytometry 등 다양한 응용 가능. 고순도 Protein A/G 정제, 보존제 없음, -20°C에서 안정적 보관.
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Thermo Fisher Scientific Placental Alkaline Phosphatase (PLAP) Monoclonal Antibody (SPM593)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM593 |
| Immunogen | Recombinant full-length human ALPP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Placental Alkaline Phosphatase (PLAP) plays an important role in regulating specific inflammatory disease processes. There are four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney types. PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) expressed in the placenta during the third trimester of gestation.
PLAP is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of PLAP is matrix mineralization; however, mice lacking functional PLAP show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects, with variable severity depending on the specific mutation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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