Thermo Fisher Scientific FLT1 Peptide Polyclonal Antibody
FLT1(또는 VEGFR1) 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ELISA에 사용 가능. 인간 시료 반응성. 항원 친화성 크로마토그래피로 정제된 액상 항체이며, 0.5 mg/mL 농도. 혈관신생 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to FLT1 peptide GNQWFI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human gastric carcinoma
- Cellular location: Secreted and Cell membrane
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase that plays a critical role in angiogenesis. Active angiogenesis is important in both pathological and physiological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation, while promoting endothelial cell proliferation, survival, and angiogenesis in adulthood.
It has a high affinity for VEGFA and relatively low kinase activity, potentially functioning as a negative regulator of VEGFA signaling by limiting free VEGFA availability and preventing its binding to KDR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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