Thermo Fisher Scientific Phospho-p53 (Ser46) Polyclonal Antibody
인간 p53 단백질의 Ser46 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 면역형광(ICC/IF)에 적합. 고순도 정제, 1 mg/mL 농도, PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-p53 (Ser46) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TP53 (Accession P04637), corresponding to amino acid residues around phosphorylated Ser46 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816216 |
Product Specific Information
Antibody detects endogenous levels of p53 only when phosphorylated at Serine 46.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulates stress-responsive genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation of p53 at various sites—including Ser15 and Ser392—affects its activation, stabilization, and association with tumor formation. p53 plays crucial roles in preventing proliferation of damaged cells, acting as an anticancer factor, and is also linked to aging and oxidative stress. Mutations in TP53 are common in human cancers and result in loss of tumor suppressor activity. Germline mutations can lead to hereditary cancer syndromes such as Li-Fraumeni syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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