Thermo Fisher Scientific Phospho-Amyloid Precursor Protein (Thr743) Polyclonal Antibody
인간, 생쥐, 랫트에서 APP Thr743 인산화 형태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. 순차 크로마토그래피로 정제된 액상 시약이며, -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APP (Accession P05067), corresponding to amino acid residues around phosphorylated Thr743 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816218 |
Product Specific Information
Antibody detects endogenous levels of APP only when phosphorylated at Thr743, a site historically referenced as Thr668.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1. APP is critical for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein that exists in several isoforms due to alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques — one of the major histopathologic features of Alzheimer’s disease. Abnormal APP regulation and processing are implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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