Thermo Fisher Scientific Phospho-BAD (Ser136) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (IHC)

1:50-1:100

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence that includes phosphorylation site of Serine 136 (S-R-S(p)-A-P) derived from mouse BAD and conjugated to KLH. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BAD,uniProtId:Q61337-1,ncbiNodeId:10090,antigenRange:134-138,antigenLength:204,antigenImageFileName:43068-100UL_BAD_Q61337-1_Rabbit.svg,antigenImageFileNamePDP:43068-100UL_BAD_Q61337-1_Rabbit_PDP.jpeg,sortOrder:2},{targetFamily:BAD,uniProtId:O35147-1,ncbiNodeId:10114,antigenRange:134-138,antigenLength:205,antigenImageFileName:43068-100UL_BAD_O35147-1_Rabbit.svg,antigenImageFileNamePDP:43068-100UL_BAD_O35147-1_Rabbit_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

Dulbecco`s PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.