Thermo Fisher Scientific SIGLEC5/SIGLEC14 Monoclonal Antibody (1A5)
인간 Siglec-5/Siglec-14 단백질을 인식하는 마우스 단클론 항체. ICC, Flow Cytometry, ELISA, IP 등에 사용 가능. 비결합형 액상 형태로 제공되며 1 mg/mL 농도. 단백질 A로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1:25–1:200 | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Functional Assay | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A5 |
| Immunogen | Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745122 |
Additional Formats
Product Specific Information
This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), also known as CD170. It is a sialic acid-binding Ig-like lectin and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.
Target Information
SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein belongs to the CD33-related subset of Siglecs and inhibits activation of several cell types, including monocytes, macrophages, and neutrophils. Binding of group B Streptococcus (GBS) to this protein contributes to GBS immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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