Thermo Fisher Scientific CD100 (SEMA4D) Monoclonal Antibody (A8), FITC

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody recognizes human Semaphorin 4D, also known as CD100, A8, BB18 or GR3.
CD100 is an 841 amino acid, approximately 150 kDa homodimeric single-pass type I transmembrane cell surface glycoprotein acting as a receptor for certain members of the plexin family.

Target Information

Semaphorins are neuronal chemorepellents that direct pioneering neurons during nervous system development.
CD100 (also known as Semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and enhances their viability in vitro.
CD100 modifies CD40–CD40L B cell signaling by promoting B cell aggregation and survival while downregulating CD23 expression.
CD72 is a lymphocyte receptor for class IV semaphorin CD100, involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T and B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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