Thermo Fisher Scientific CD6 Recombinant Rabbit Monoclonal Antibody (39)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select the best production candidates.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Mouse CD6 / Cluster of Differentiation 6.

Target Information

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6–ALCAM-mediated cell adhesion is important for T cell proliferation. CD6 may exert its functions via association with CD5, potentially fine-tuning CD5 signaling. Ligation of CD6 has an antiapoptotic role in chronic lymphocytic leukemia B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.