Thermo Fisher Scientific Androgen Receptor Monoclonal Antibody (H7507)
Androgen Receptor(AR)을 인식하는 Mouse monoclonal antibody(H7507). Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며 비결합형(Unconjugated) 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–20 µg/mL | - |
| ELISA | 0.3 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H7507 |
| Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human AR (2–53 aa). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at −20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532193 |
Product Specific Information
This antibody specifically recognizes human androgen receptor (AR) and cross-reacts with mouse and rat AR.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is critical for the development and function of male reproductive organs such as the prostate and epididymis and also functions in nonreproductive tissues including muscle, hair follicles, and brain.
Abnormalities in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene can cause complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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