Thermo Fisher Scientific CHK2 Recombinant Rabbit Monoclonal Antibody (2W5N3)
CHK2 단백질 인식 토끼 단클론 항체로, Western blot, IHC, ELISA에 적합합니다. 인간 및 마우스 시료에 반응하며, HEK293 발현 시스템에서 제조되었습니다. DNA 손상 반응 연구 및 암 관련 단백질 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:8,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2W5N3 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human Chk2 (O96017) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849196 |
Product Specific Information
Immunogen sequence:
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ
Target Information
Gene: CHEK2 (CHK2)
Function: CHK2 is a serine/threonine kinase and a key component of the DNA damage checkpoint pathway.
Mutations in CHK2 are linked to various cancers, including Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins such as BRCA1, aiding in DNA repair and cell survival.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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