Thermo Fisher Scientific Caspase 8 Recombinant Rabbit Monoclonal Antibody (ARC0028)
Recombinant rabbit monoclonal antibody targeting human Caspase 8. Validated for Western blot and ELISA applications. High purity via affinity chromatography. Supplied as liquid form with 0.43 mg/mL concentration. Suitable for apoptosis and neurodegener...
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Thermo Fisher Scientific Caspase 8 Recombinant Rabbit Monoclonal Antibody (ARC0028)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0028 |
| Immunogen | Synthetic peptide corresponding to amino acids 200–300 of human Caspase-8 (UniProt Q14790) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849198 |
Product Specific Information
Immunogen sequence:
EELCGVMTIS DSPREQDSES QTLDKVYQMK SKPRGYCLII NNHNFAKARE KVPKLHSIRD RNGTHLDAGA LTTTFEELHF EIKPHDDCTV EQIYEILKIY Q
Target Information
Caspase 8 (CASP8) is a cysteine-aspartic acid protease involved in apoptosis execution. It exists as an inactive proenzyme that requires proteolytic processing to form an active heterodimeric enzyme. Caspase 8 interacts with FADD through its death effector domain and activates downstream caspases, including Caspase 9, committing the cell to apoptosis. It is implicated in neurodegenerative diseases such as Huntington’s disease and reacts with Jurkat cells and Tonsil. Overexpression induces apoptosis, which can be inhibited by ICE family-specific inhibitors. Multiple alternatively spliced variants exist, though not all have been fully characterized.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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