Thermo Fisher Scientific TFAM Recombinant Rabbit Monoclonal Antibody (JM32-44)
TFAM 단백질을 인식하는 Recombinant Rabbit Monoclonal 항체로, Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM32-44 |
| Immunogen | Synthetic peptide within Human mtTFA aa 41–90 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810041 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and individual clones are screened to select optimal candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Mitochondrial transcription factor A (TFAM) is encoded by nuclear genes and transported to mitochondria, where it maintains and regulates mitochondrial DNA (mtDNA) replication and transcription.
TFAM interacts with autophagy proteins such as LC3 via its LC3 interacting region (LIR) motif, aiding in the removal of leaked mtDNA and controlling inflammation.
TFAM levels influence mitochondrial function across tissues — high levels can repress mtDNA expression in skeletal muscle, while in the heart, balanced TFAM-to-mtDNA ratios preserve oxidative phosphorylation (OXPHOS) capacity.
Disruptions in TFAM function are linked to mitochondrial dysfunction and diseases related to mtDNA stress, including neurodegeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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