Thermo Fisher Scientific PPARGC1B Recombinant Rabbit Monoclonal Antibody (JM33-24)
PPARGC1B 단백질을 인식하는 재조합 토끼 단일클론 항체로 높은 특이성과 민감도를 제공합니다. Western blot, Flow cytometry, Immunoprecipitation 등에 적합합니다. HEK293 발현 시스템 기반으로 제작되어 로트 간 일관성이 우수하며, 동물 유래 성분이 없습니다.
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Thermo Fisher Scientific PPARGC1B Recombinant Rabbit Monoclonal Antibody (JM33-24)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM33-24 |
| Immunogen | Synthetic peptide within Human PGC1 beta aa 974–1023 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810042 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
PGC-1 beta is a tissue-specific co-activator that enhances the activity of estrogen receptor alpha (ER-α). The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-α in an estrogen-dependent manner. Ectopic expression of this protein increases mitochondrial number and basal oxygen consumption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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