Thermo Fisher Scientific PPARb Polyclonal Antibody
PPARβ 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 검증 완료. 인간 시료 반응성, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific PPARβ Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length recombinant protein of human PPAR-beta (UniProt ID: Q03181-1; Antigen range: 1–441) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: HT-29
- Cellular location: Nuclear
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells.
PPARs mediate a variety of biological processes and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.
This protein is a potent inhibitor of ligand-induced transcription activity of PPARα and PPARγ. It may function as an integrator of transcription repression and nuclear receptor signaling.
Expression of this gene is elevated in colorectal cancer cells and can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/β-catenin signaling pathway.
Knockout studies in mice suggest roles in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Usage Restriction
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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