Thermo Fisher Scientific PEDF Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PEDF/SERPINF1. Validated for Western blot with dilution 1:500–1:2,000. Suitable positive controls include human serum and multiple tissue lysates. Useful for studying anti-angiogenic and neuroprotective mech...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 301–400 of human PEDF/SERPINF1 (NP_0026063) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914083 |
Product Specific Information
- Positive test controls: Human serum, U2OS, Mouse spleen, Mouse kidney, Rat liver
- Target localization: Melanosome, Secreted
Immunogen sequence:
IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP IKLTQVEHRA GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD
Target Information
PEDF (Pigment Epithelium-Derived Factor) is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. PEDF induces apoptosis in proliferating endothelial cells and inhibits angiogenic factors such as VEGF and FGF-2. It also provides neuroprotection by suppressing neuronal apoptosis caused by oxidative or excitotoxic stress.
PEDF binds to its receptor PEDF-R, a lipase-linked cell membrane receptor, which facilitates signaling and functional studies. Due to its multifunctional properties, PEDF is a potential therapeutic target for age-related macular degeneration (AMD), proliferative diabetic retinopathy (PDR), and other angiogenesis-related diseases, including certain cancers.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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