Thermo Fisher Scientific MMAF Monoclonal Antibody (A5G12)
Thermo Fisher Scientific의 MMAF Monoclonal Antibody (A5G12)는 MMAF-OVA를 면역원으로 한 Mouse IgG1 단일클론 항체입니다. ELISA에 적합하며, Protein G로 정제된 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
- ELISA
- Tested Dilution: 1:5,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A5G12 |
| Immunogen | MMAF coupled with OVA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911678 |
Product Specific Information
This product has been tested in direct ELISA.
Target Information
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent used in the approved drug belantamab mafodotin for multiple myeloma and in experimental antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
In International Nonproprietary Names for MMAF-antibody conjugates, "mafodotin" refers to MMAF plus its attachment structure to the antibody.
MMAF acts as an antimitotic agent by inhibiting tubulin polymerization, thereby blocking cell division. When linked to antibodies targeting cancer cell structures, MMAF accumulates selectively in those cells.
Chemically, MMAF is desmethyl-auristatin F, meaning its N-terminal amino group has only one methyl substituent instead of two as in auristatin F.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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