Thermo Fisher Scientific Thymidine Phosphorylase Monoclonal Antibody (A1A8)
인간 Thymidine Phosphorylase를 인식하는 Mouse monoclonal antibody. Western blot에 최적화되어 있으며, 단백질 정제는 Protein G 방식으로 수행됨. 2 mg/mL 농도의 액상 형태로 제공되며, 세포질 및 핵 내 단백질 검출에 적합. 연구용으로만 사용 가능.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A1A8 |
| Immunogen | Recombinant protein within human Thymidine Phosphorylase (aa 1–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911680 |
Product Specific Information
- Positive Control: Human lung tissue lysates
- Subcellular Location: Cytosol, nuclear
Target Information
Thymidine Phosphorylase (also known as PD-ECGF or gliostatin) is a platelet-derived endothelial growth factor. In the presence of inorganic orthophosphate, it catalyzes the reversible phosphorolytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. This enzyme is chemotactic and mitogenic for endothelial cells and acts as a non-heparin-binding angiogenic factor present in platelets. It is also involved in the conversion of fluoropyrimidines—cytotoxic agents used in cancer therapy—into active cytotoxic metabolites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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