Thermo Fisher Scientific BMP-8B Polyclonal Antibody
Thermo Fisher Scientific BMP-8B Polyclonal Antibody는 인간, 생쥐, 랫트 시료에서 BMP8 단백질을 검출합니다. Rabbit IgG 기반의 폴리클로날 항체로, Western Blot, ELISA, Dot blot에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:2,000 |
| Dot blot (DB) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide LQTLRAGDEGWLVL conjugated to KLH, corresponding to amino acids 184–197 of BMP8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris glycine, pH 7.4–7.9, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2259025 |
Product Specific Information
PA1-31216 detects BMP8 from rat, mouse, and human samples.
Target Information
BMP-8B encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily. Ligands of this family bind various TGF-beta receptors, leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.
The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. BMP-8B stimulates thermogenesis in brown adipose tissue, and its expression may be downregulated in pancreatic cancer. BMP-8B may have arisen from a gene duplication event, with its duplicate also present on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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