Thermo Fisher Scientific NOXA Polyclonal Antibody
Thermo Fisher Scientific의 NOXA Polyclonal Antibody는 인간 및 생쥐 시료에 반응하는 rabbit IgG 항체로, Western blot, IHC, ICC/IF에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 단백질 G 정제 및 PBS buffer에 보관됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:250 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to residues 51–66 and 75–90 of mouse Noxa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2166692 |
Product Specific Information
Suggested positive control: human, mouse, or rat thymus tissue lysate or protein, antigen standard for PMAIP1 (transient overexpression lysate).
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, encodes a protein belonging to the subfamily of BH3-only proapoptotic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, activating caspase-9. Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Elevated levels of p53 and Noxa are associated with impaired tumor development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA1-41010_NOXA_Q9JM54-1_Rabbit.svg, PA1-41010_NOXA_Q9JM54-1_Rabbit_PDP.jpeg)
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