Thermo Fisher Scientific TRF2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

15 µg/mL

-

Immunocytochemistry (ICC/IF)

1:10-1:500

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-Dependent

-

Immunoprecipitation (IP)

2 µg/ million cells

-

ChIP assay (ChIP)

1:20-1:1,000

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Baculovirus expressed His-tagged whole length TRF2 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRF2,uniProtId:Q15554-3,ncbiNodeId:9606,antigenRange:1-542,antigenLength:542,antigenImageFileName:PA1-41023_TRF2_Q15554-3_Goat.svg,antigenImageFileNamePDP:PA1-41023_TRF2_Q15554-3_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2201476

Product Specific Information

Suggested positive control: antigen standard for TERF2 (transient overexpression lysate), Daudi, HeLa, HL-60, or Jurkat.

Target Information

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.