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Thermo Fisher Scientific Phospho-CHK1 (Ser345) Recombinant Rabbit Monoclonal Antibody (PS01-17)
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Phospho-CHK1 (Ser345) 특이적 재조합 토끼 단클론 항체로, 인간 CHK1 단백질의 Ser345 인산화 부위를 인식합니다. Western blot 및 ICC/IF에 최적화되어 있으며, 고순도 Protein A 정제 및 안정적 PBS/BSA/glycerol 포뮬레이션으로 제공됩니다. 연구용으로만 사용 가능합니다.
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마지막 업데이트 2025. 08. 04. 오후 07:25
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Thermo Fisher Scientific MA545974 Phospho-CHK1 (Ser345) Recombinant Rabbit Monoclonal Antibody (PS01-17) 100 ul pk판매 단위 pk ·
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705,800원VAT 포함 776,380원
Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-CHK1 (Ser345) Recombinant Rabbit Monoclonal Antibody (PS01-17)
Thermo Fisher Scientific Phospho-CHK1 (Ser345) Recombinant Rabbit Monoclonal Antibody (PS01-17)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PS01-17 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding Ser345 of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2937395 |
Product Specific Information
- Predicted band size: 54 kDa
- Positive Controls: HeLa treated with Etoposide cell lysate, HeLa treated with Hydroxyurea cell lysate, HeLa treated with 4 mM Hydroxyurea for 20 hours
- Subcellular Location: Nucleus, Chromosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
- Sequence Similarities: 100% Mouse/Rat
- Tissue Specificity: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine, and colon
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in maintaining genomic integrity by preventing replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network. CHK1 inhibition leads to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making it a promising therapeutic target for cancer treatment, particularly in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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