Thermo Fisher Scientific IL-1 beta Polyclonal Antibody
IL-1 beta 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/50% 글리세롤 용액 형태로 제공. 염증성 사이토카인 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Interleukin 1 Beta (amino acids 117–268) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903718 |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form through inflammasome activation. IL-1β lacks a classical signal peptide and is secreted via a noncanonical pathway. It signals through IL-1RI and IL-1RII receptors, shared with IL-1α, and its activity is modulated by IL-1 Receptor Antagonist (IL-1RA). IL-1β is critical for innate immune defense and inflammation, and elevated levels are associated with chronic inflammatory diseases.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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