Thermo Fisher Scientific TGM2 Recombinant Rabbit Monoclonal Antibody (7E1)
TGM2 단백질을 인식하는 토끼 재조합 단클론 항체로 Western blot에 최적화됨. HEK293 세포에서 발현되며, 높은 특이성과 재현성을 제공. PBS 기반 버퍼에 보관되며, 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7E1 |
| Immunogen | A synthesized peptide derived from human TGM2 (amino acids 593–608, UniProt ID: P21980-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C (preferred) |
| Shipping Conditions | Wet ice |
| RRID | AB_2898203 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase, TGase 2) has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains. It may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity contributes to protein polymerization, including Aβ peptide, β-amyloid precursor protein, and tau protein, leading to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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