Thermo Fisher Scientific TGM2 Recombinant Rabbit Monoclonal Antibody (7E1)

Applications

• Western Blot (WB): 1:500–1:5,000

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase, TGase 2) has four domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains. It may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity contributes to protein polymerization, including Aβ peptide, β-amyloid precursor protein, and tau protein, leading to neurofibrillary tangle formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.