Thermo Fisher Scientific GCK Recombinant Rabbit Monoclonal Antibody (ARC1226)
Thermo Fisher Scientific의 GCK Recombinant Rabbit Monoclonal Antibody (ARC1226)는 인간, 마우스, 랫트 시료에서 Glucokinase 단백질 검출에 적합합니다. Western blot, ELISA, IP에 사용 가능하며, 고순도 Affinity Chromatography로 정제된 액상 항체입니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- MA535665
- 판매단위
- pk
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific GCK Recombinant Rabbit Monoclonal Antibody (ARC1226)
Applications
- Western Blot (WB): 1:1,000–1:4,000
- ELISA: 1 µg/mL
- Immunoprecipitation (IP): 0.5 µg–4 µg antibody for 200 µg–400 µg extracts
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1226 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 271–421 of human Glucokinase (GCK) (P35557) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849565 |
Product Specific Information
Immunogen sequence:
LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK E
Target Information
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase: one in pancreatic islet beta cells and two in liver. The protein localizes to the outer membrane of mitochondria. Unlike other hexokinases, this enzyme remains active while glucose is abundant and is not inhibited by glucose-6-phosphate. Mutations in this gene are associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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