Thermo Fisher Scientific HLA-E Polyclonal Antibody
Thermo Fisher Scientific의 HLA-E Polyclonal Antibody는 인간 HLA-E 단백질을 인식하는 고순도 항체입니다. Western blot에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 면역펩티도믹스 연구 및 신항원 분석에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human HLA-E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803814 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane and binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
The heavy chain is approximately 45 kDa and its gene contains 8 exons:
- Exon 1: leader peptide
- Exons 2–3: alpha1 and alpha2 domains (peptide-binding regions)
- Exon 4: alpha3 domain
- Exon 5: transmembrane region
- Exons 6–7: cytoplasmic tail
HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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