Thermo Fisher Scientific Phospho-WWTR1 (Ser311) Recombinant Superclonal Antibody (14HCLC)
Phospho-WWTR1 (Ser311) 단백질을 인식하는 재조합 Superclonal 항체로, 인간 시료에 반응하며 ICC/IF에 적합합니다. 다중 클론 혼합으로 높은 민감도와 재현성을 제공합니다. Protein A 정제, 액상 형태로 4°C 보관 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 14HCLC |
| Immunogen | Peptide corresponding to human Phospho-WWTR1 (Ser311) [aa307–aa314] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784607 |
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Cat, and Sheep.
Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies. Each lot contains a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting as a downstream target in the Hippo signaling pathway, which regulates organ size and tumor suppression by controlling proliferation and apoptosis.
This pathway involves kinase cascades (STK3/MST2, STK4/MST1, LATS1/2, MOB1) that modulate YAP1 and WWTR1/TAZ activity. WWTR1 enhances gene activation (PAX8, NKX2-1/TTF1), regulates SMAD nuclear accumulation, and contributes to stem-cell self-renewal, proliferation, and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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