Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Caspase-12 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot에 사용 가능. ER 스트레스 경로 연구에 적합하며, murine spleen lysate를 양성 대조군으로 추천. 액상 형태로 제공되며 -20°C에서 보관.
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- PA112508
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 100–116 of the murine caspase-12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070985 |
Product Specific Information
A suggested positive control for this product is murine spleen tissue lysate.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main routes, involving key apoptotic proteases caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress pathway is the third apoptotic pathway, in which caspase-12 is involved.
Caspase-12 is localized to the ER but not to the cytoplasm or mitochondria. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 co-localizes in the ER with several proteins involved in Alzheimer’s disease, including γ-secretase presenilin and β-amyloid precursor protein (APP). It mediates cytotoxicity induced by amyloid-β and is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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