Thermo Fisher Scientific CD40 Recombinant Rat Monoclonal Antibody (3/23)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: This antibody is specific for murine CD40, a 48 kD type I transmembrane glycoprotein also known as Bp50.

Target Information

The CD40 antigen is a single-chain glycoprotein and a member of the tumor necrosis factor/nerve growth factor superfamily. It shows significant homology to the Hodgkin’s disease-associated antigen CD30. CD40 is expressed on all B cells except plasma cells and is also found on some epithelial cells, carcinomas, and lymphoid dendritic cells.
CD40 is essential in mediating immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The AT-hook transcription factor AKNA regulates CD40 expression, facilitating homotypic cell interactions.
Adaptor protein TNFR2 interacts with CD40 and mediates signal transduction. The CD40–CD40L interaction is critical for amyloid-beta-induced microglial activation, an early event in Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct CD40 isoforms have been reported.
Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.