Thermo Fisher Scientific Acetyl-CoA Carboxylase Polyclonal Antibody
Western blot, IHC, ICC, Flow cytometry, IP 등 다양한 응용에 사용 가능한 Acetyl-CoA Carboxylase 폴리클로날 항체. Rabbit IgG 기반으로 항원 친화 크로마토그래피로 정제됨. Human, Mouse 등 다양한 종에 반응하며, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:50 | - |
| Flow Cytometry (Flow) | 1:50 | - |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rat |
| Published Species | Chicken, Human, Yeast |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser523 of human acetyl CoA carboxylase alpha1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 17 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979444 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.
There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is regulated at both transcriptional and translational levels and is also modulated by phosphorylation/dephosphorylation of serine residues and allosteric transformation by citrate or palmitoyl-CoA.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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