Thermo Fisher Scientific Human Lass5 Synthetic Peptide
인간 LASS5 단백질의 N말단 18개 아미노산 서열에 해당하는 합성 펩타이드로, 항체 PA5-20570의 블로킹 펩타이드로 사용 가능. 세라마이드 합성 관련 연구에 적합하며, 정제된 액상 형태로 제공. PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human LASS5.
PEP-0690 can be used as a blocking peptide with polyclonal antibody PA5-20570.
Target Information
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family (LASS1–6) are involved in ceramide synthesis during cell growth regulation and cancer differentiation.
LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum multi-pass membrane protein functioning as a dihydro-ceramide synthase. It synthesizes sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner, using palmitoyl-CoA as an acyl donor.
It is involved in the synthesis of C14, C16, and C18-ceramides and is the most abundantly expressed ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially corrects growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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