Thermo Fisher Scientific Human MED28 Synthetic Peptide
Human MED28 단백질의 중심부 17개 아미노산 서열을 기반으로 한 합성 펩타이드. Polyclonal antibody PA5-20572의 blocking peptide로 사용 가능. Assay 의존적 적용. PBS 완충액에 0.1% BSA 함유, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the center of human MED28.
PEP-0692 can be used as a blocking peptide with polyclonal antibody PA5-20572.
Target Information
The mediator complex is a multi-protein transcriptional co-activator expressed ubiquitously in eukaryotes and required for RNA polymerase II transcription by DNA-binding transcription factors.
MED28 (also known as Magicin) is one of the proteins in this complex, expressed in many cell lines and tissues. Down-regulation of MED28 in NIH3T3 cells induces genes associated with smooth muscle cell differentiation, while overexpression represses SMC gene expression.
MED28 can form a ternary complex with Grb2 and Merlin (the neurofibromatosis 2 tumor suppressor protein), suggesting a role in Merlin’s tumor suppressive activity.
It has also been identified as an HIV dependency factor (HDF), indicating potential as a drug target in HIV treatment. At least two isoforms of MED28 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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