Thermo Fisher Scientific Human Lass5 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human LASS5.
PEP-0689 can be used as a blocking peptide with polyclonal antibody PA5-20569.

Target Information

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6), and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation.
LASS5, also called Trh4, is a 392-amino-acid endoplasmic reticulum multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16, and C18-ceramide.
LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially corrects growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.