Thermo Fisher Scientific Phospho-Chemokine Receptor 5 (Ser342) Polyclonal Antibody
인간 CCR5 Ser342 인산화 부위를 인식하는 Rabbit 폴리클로날 항체로 HIV 관련 연구에 적합. Western blot에 1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 용액에 0.02% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- 7TM0062C
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CCR5 around the phosphorylation site of Ser342 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
Several G protein-coupled receptors, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, as well as newly identified human molecules GPR15, STRL33, GPR1, and V28, act as HIV coreceptors.
Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry of human white blood cells.
CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1.
CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and virus entry into target cells.
The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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