Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (4A7)
TNFRSF18(GITR) 단백질을 표적하는 마우스 단클론 항체로 ELISA에 적합. 인간 반응성, 비결합형 액상 제품. Affinity chromatography로 정제되었으며 PBS(pH 7.4)에 보존제 없음. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (4A7)
Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A7 |
| Immunogen | TNFRSF18 (NP_004186.1, 26–161 a.a) partial recombinant protein with mouse IgG2a-Fc tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein encoded by the TNFRSF18 gene mapped to 1p36.33.
This gene encodes a TNF-receptor superfamily member. The receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells.
Knockout studies in mice suggest its role in regulation of CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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