Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (4A7)

Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (4A7)

Applications

• ELISA (ELISA)

Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE

Target Information

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein encoded by the TNFRSF18 gene mapped to 1p36.33.
This gene encodes a TNF-receptor superfamily member. The receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells.
Knockout studies in mice suggest its role in regulation of CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.