Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (3B2)
TNFRSF18(GITR) 단백질을 인식하는 Mouse IgG1 단일클론 항체. ELISA에 최적화되어 있으며 인간 시료 반응성. PBS 버퍼 내 보존제 무첨가, -20°C 보관. 연구용으로 T세포 활성 및 면역 조절 연구에 적합.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B2 |
| Immunogen | TNFRSF18 (NP_004186.1, 26–161 a.a.) partial recombinant protein with mouse IgG2a-Fc tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans. It is mapped to 1p36.33 and belongs to the TNF-receptor superfamily.
This receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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