Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (1E10)
TNFRSF18(GITR) 단백질을 인식하는 Mouse IgG1 단클론 항체로, ELISA에 적합합니다. 인간 시료에 반응하며, PBS(pH 7.4) 완충액에 보존됩니다. Affinity chromatography로 정제된 액상 제품으로, -20°C에서 보관합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E10 |
| Immunogen | TNFRSF18 (NP_004186.1, 26–161 a.a.) partial recombinant protein with mouse IgG2a-Fc tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans.
It is mapped to chromosome 1p36.33, and encodes a receptor belonging to the TNF-receptor superfamily.
This receptor shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance via CD25(+)CD4(+) regulatory T cells.
Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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