Thermo Fisher Scientific CD2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Positive Control: K562, THP-1
• Predicted Reactivity: Rhesus Monkey (93%), Chimpanzee (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage, expressed on all peripheral blood T cells.
It is one of the earliest T-cell markers, present on >95% of thymocytes, and also found on some natural killer cells, but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2’s role as an erythrocyte receptor or associated molecule.
CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells.
Low affinity in solution is compensated at the cell–cell interface, providing tight adhesion.
T cell activation increases CD2 expression and mobility, enhancing CD2–CD58 contact and strengthening intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and helps control infection.
Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to thymus absence.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.