Thermo Fisher Scientific CD66a (CEACAM1) Monoclonal Antibody (CC1), APC, eBioscience
CD66a(CEACAM1)을 인식하는 마우스 단클론 항체(CC1)로, APC 형광체 결합. Flow Cytometry에 최적화되어 있으며, 마우스 시료에서 검증됨. 651/660 nm의 Excitation/Emission 특성을 가지며, 4°C 암소 보관 권장. 연구용으로만 사용.
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Applications
- Flow Cytometry (Flow): Tested at ≤ 0.06 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10717250 |
Additional Formats
Product Specific Information
Description:
The monoclonal antibody CC1 recognizes CD66a (CEACAM1), also known as carcinoembryonic antigen-related cell adhesion molecule 1, biliary glycoprotein (BGP). CD66a is expressed on brush borders, epithelial, and endothelial cells. In hematopoietic cells, expression is abundant on B cells, NK cells, monocytes, DCs, and granulocytes.
In mice, resting T lymphocytes do not express CD66a, as confirmed by lack of staining with CC1 antibody. CD66a expression levels have been used to identify malignancies in humans and play a regulatory role in BCR activation of B lymphocytes.
An alternate allele, CEACAM1b, is expressed in SJL mice; therefore, CC1 does not stain SJL tissue.
The monoclonal CC1 antibody has been shown to block viral infection and enhance B cell proliferation when combined with IgM crosslinking.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes at ≤ 0.06 µg/test (100 µL final volume; 10⁵–10⁸ cells/test).
Recommended Laser: Red Laser (Excitation 633–647 nm; Emission 660 nm)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CEACAM1 (CD66a) belongs to the carcinoembryonic antigen (CEA) gene family within the immunoglobulin superfamily.
It functions as a cell adhesion molecule expressed on leukocytes, epithelial, and endothelial cells, mediating both homophilic and heterophilic interactions.
Biological roles include:
- Regulation of tissue differentiation and 3D structure
- Angiogenesis and apoptosis
- Tumor suppression and metastasis regulation
- Modulation of innate and adaptive immune responses
Multiple transcript variants and isoforms have been reported, with two full-length forms identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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