Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (EP72), PE

Applications

• Flow Cytometry (Flow): 0.2 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA5-28798)
• Biotin (MA5-28795)
• FITC (MA5-28796)
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a critical role in T-cell signal transduction, differentiation, and activation. CD8 is primarily expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.

CD8α is essential for MHC-I binding and can also form homodimers expressed on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes on antigen-presenting cells recruits Lck kinase, triggering lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in eliminating pathogens and tumor cells. Differentiation of naive CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지