Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (EP72)

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Additional Formats

• Biotin
• FITC
• PE
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a key role in signal transduction and T cell differentiation and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for major histocompatibility complex class I (MHC-I) molecules.
CD8α is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Engagement of MHC-I/peptide complexes by antigen-presenting cells triggers Lck kinase recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance, and differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.