Thermo Fisher Scientific ACE2 Polyclonal Antibody
ACE2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB 및 IHC 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관.
- 카탈로그번호
- PA520040
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ACE2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–15 µg/mL | – |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | View 1 publication |
Product Specifications
| Item | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids near the C-terminus of human ACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153159 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 90 kDa.
- Suggested positive control: human kidney tissue lysate.
- PA5-20040 can be used with blocking peptide PEP-0159.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology.
In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis.
ACE2 is also a functional receptor for the SARS coronavirus.
Its normal function is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
Lack of ACE2 expression in knockout mice leads to severely reduced cardiac contractility, indicating its importance in heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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