Thermo Fisher Scientific HDAC8 Polyclonal Antibody
HDAC8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 고순도 항원 친화 정제 제품입니다. 액상 형태로 1 mg/mL 농도이며, 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:10–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 2–45 of Human HDAC8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2802947 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, largely influenced by the acetylation and deacetylation of nucleosomal histones. Acetylation increases accessibility to transcription factors, while deacetylation is linked to transcriptional silencing.
Several mammalian nuclear histone acetylases have been identified, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase with unique tissue distribution and nuclear localization. It plays roles in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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