Thermo Fisher Scientific PDCD4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, and Orangutan

Target Information

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover as well as tumor formation. During this process, expression patterns of numerous genes are radically altered. One such gene, PDCD4, encodes a tumor suppressor protein whose expression is lost in breast, colon, lung, and prostate carcinomas.
PDCD4 inhibits the helicase activity of eukaryotic translation initiation factor 4A and suppresses transactivation mediated by transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, reducing its ability to interfere with AP-1-responsive promoter activation by c-Jun. There are two known isoforms of PDCD4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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