Thermo Fisher Scientific PDCD4 Polyclonal Antibody
PDCD4 단백질을 표적하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 적합합니다. 다양한 종(마우스, 랫, 치킨, 오랑우탄)에 반응 예측됩니다. 1 mg/mL 농도의 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 419 and 469 of human programmed cell death 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, and Orangutan
Target Information
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover as well as tumor formation. During apoptosis, many genes show altered expression patterns. One such gene, PDCD4, encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung, and prostate.
PDCD4 can bind to and inhibit the helicase activity of eukaryotic translation initiation factor 4A and suppress AP-1-mediated transactivation and transformation. The kinase Akt regulates PDCD4 by phosphorylation, reducing its interference with AP-1 promoter activity.
There are two known isoforms of PDCD4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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