Thermo Fisher Scientific PDCD4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, and Orangutan

Target Information

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover as well as tumor formation. During apoptosis, many genes show altered expression patterns. One such gene, PDCD4, encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung, and prostate.
PDCD4 can bind to and inhibit the helicase activity of eukaryotic translation initiation factor 4A and suppress AP-1-mediated transactivation and transformation. The kinase Akt regulates PDCD4 by phosphorylation, reducing its interference with AP-1 promoter activity.
There are two known isoforms of PDCD4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.