Thermo Fisher Scientific IkB beta Recombinant Rabbit Monoclonal Antibody (SN0648)
Human IκB beta 단백질을 인식하는 recombinant rabbit monoclonal antibody입니다. Western blot, IHC(P), ICC/IF에 사용 가능합니다. 높은 특이성과 재현성을 제공하며, lot 간 일관성이 우수합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN0648 |
| Immunogen | Synthetic peptide within Human IKB beta aa 322–356 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809547 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The specific antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
The NF-κB/Rel transcription factors reside in the cytosol in an inactive state, complexed with inhibitory IκB proteins. Activation of NF-κB typically occurs through phosphorylation-induced, proteasome-mediated degradation of IκB.
A key regulatory step involves activation of the IκB kinase (IKK) complex, composed of catalytic subunits IKKα and IKKβ and regulatory subunit IKKγ. Activation depends on phosphorylation at Ser177 and Ser181 in IKKβ (Ser176 and Ser180 in IKKα), leading to conformational changes and kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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