Thermo Fisher Scientific ATM Monoclonal Antibody (3E8)
ATM 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, IP 등 다양한 응용에 적합합니다. 인간 및 설치류 등 여러 종에 반응하며, 단백질 G 정제 및 PBS 버퍼에 보존됩니다. DNA 손상 복구 연구용으로 권장됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunoprecipitation (IP) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E8 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 980–1512 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557653 |
Product Specific Information
- Recommended positive controls: Raji, HeLa, or Akata
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein that phosphorylates other proteins involved in cell-cycle regulation, including P53, Mdm2, BRCA1, and SMC1.
ATM plays a critical role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation. Cells lacking functional ATM are hypersensitive to radiation and show impaired DNA synthesis inhibition and delayed p53 induction.
DNA damage activates ATM kinase, triggering a cascade of reactions regulating cell cycle, apoptosis, and DNA damage repair.
ATM also interacts with Nbs1 and Chk2 in the E2F1 pathway, linking it to apoptosis mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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