Thermo Fisher Scientific HPV Type 16 E7 Monoclonal Antibody (716-325)
HPV Type 16 E7 단백질을 검출하는 Mouse monoclonal antibody입니다. Western blot과 ELISA에 사용 가능하며, 3.6 mg/mL 농도의 액상 형태로 제공됩니다. Protein G로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific HPV Type 16 E7 Monoclonal Antibody (716-325)
Applications
- Western Blot (WB): Assay-dependent
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 716-325 |
| Immunogen | Human papilloma virus oncoprotein E7, Type 16 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.6 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_559522 |
Product Specific Information
MA1-23087 detects HPV-16 in Virus samples.
Target Information
The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15 kDa), zinc-binding phosphoproteins localized in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses.
The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A.
Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22–26) involved in binding to the tumour suppressor protein pRb.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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