Thermo Fisher Scientific HPV Type 16 E7 Monoclonal Antibody (716-325)

Thermo Fisher Scientific HPV Type 16 E7 Monoclonal Antibody (716-325)

Applications

• Western Blot (WB): Assay-dependent
• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

MA1-23087 detects HPV-16 in Virus samples.

Target Information

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15 kDa), zinc-binding phosphoproteins localized in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses.
The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A.
Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22–26) involved in binding to the tumour suppressor protein pRb.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.